Sub DoMAcro()
Dim lastRow As Integer
lastRow = Cells(1000, 16).End(xlUp).Row
Range(Cells(7, 16), Cells(lastRow, 16)).Replace What:="0", Replacement:="", LookAt:=xlPart, _
SearchOrder:=xlByRows, MatchCase:=False, SearchFormat:=False, ReplaceFormat:=False
End Sub