Mono applications would normally compile to bytecode which is and would require JIT (just in time) compilation to run them thus a .Net framework or Mono framework is required. However, in the case of iOS and Android, Mono application compile to native code. Therefore, in the eyes of Apple, there is no third layer, Apple will never ban Mono. So you can feel free to develop with MonoTouch and distribute your apps. To ensure you further, there are various of Mono applications (including games and applications) on the AppStore that have been around for a long time.
