Among other text and visual aids on a form submission, post-validation, I\'m coloring my input boxes red to signify the interactive area needing attention.
On Chrome
Yes, it would be a major headache, which in my opinion isnt worth the return. Maybe you could tweak your UI strategy a bit, and instead of coloring the box red, you could color the borders red, or put a small red tape beside it (like the gmails "Loading" tape) which fades away when the box is in focus.