The top two in my mind have to be ones with language support:
IEnumerable (and IEnumerable): for
use with foreach and LINQ
IDisposable: for resources requiring
cleanup, used with using
Beyond that...
IComparable and IComparer: for generalized sorting
IEquatable and IEqualityComparer: for generalized equality
IList and ICollection: for mutable collections
IDictionary: for lookup collections