I am developing a front end which consumes JSON services provided by a server.
I happily use HTTP of Angular2 and I can catch errors via .catch() operator.         
        
If you would like to handle this event globally in your application I recommend using slightly modified Nicolas Henneaux's answer https://stackoverflow.com/a/37028266/1549135
Basically you can check for error.status === 0 which happens when the net::ERR_CONNECTION_REFUSED error occurs.
The complete module file:
import { Request, XHRBackend, BrowserXhr, ResponseOptions, XSRFStrategy, Response } from '@angular/http';
import { Observable } from 'rxjs/Observable';
import 'rxjs/add/operator/catch';
import 'rxjs/add/observable/throw';
export class AuthenticationConnectionBackend extends XHRBackend {
  constructor(_browserXhr: BrowserXhr, _baseResponseOptions: ResponseOptions, _xsrfStrategy: XSRFStrategy) {
    super(_browserXhr, _baseResponseOptions, _xsrfStrategy);
  }
  createConnection(request: Request) {
    let xhrConnection = super.createConnection(request);
    xhrConnection.response = xhrConnection.response.catch((error: Response) => {
      if (error.status === 0){
        console.log("Server is down...")
      }
      ...
      return Observable.throw(error);
    });
    return xhrConnection;
  }
}
Module file:
import { BrowserModule } from '@angular/platform-browser';
import { NgModule } from '@angular/core';
import { CommonModule } from '@angular/common';
import { HttpModule, XHRBackend } from '@angular/http';
import { AppComponent } from './app.component';
import { AuthenticationConnectionBackend } from './authenticated-connection.backend';
@NgModule({
    bootstrap: [AppComponent],
    declarations: [
        AppComponent,
    ],
    entryComponents: [AppComponent],
    imports: [
        BrowserModule,
        CommonModule,
        HttpModule,
    ],
    providers: [
        { provide: XHRBackend, useClass: AuthenticationConnectionBackend },
    ],
})
export class AppModule {
}