Easiest and Simplest method of solving this problem is using re
import re
search_list = ['one', 'two', 'there']
long_string = 'some one long two phrase three'
if re.compile('|'.join(search_list),re.IGNORECASE).search(long_string): #re.IGNORECASE is used to ignore case
# Do Something if word is present
else:
# Do Something else if word is not present