I only know of one instance using registers is via CtrlR* whereby I paste text from a clipboard.
What are other uses of registers?
My favorite feature is the ability to append into registers by using capital letters. For example, say you want to move a subset of imports from buffer X to buffer Y.
x1 in buffer X."ayy to replace register a with the content of line x1.x5."Ayy (capital A) to append line x5 at the end of register a."ap to paste