I only know of one instance using registers is via CtrlR* whereby I paste text from a clipboard.
What are other uses of registers?
The black hole register _ is the /dev/null of registers.
_
/dev/null
I use it in my vimrc to allow deleting single characters without updating the default register:
noremap x "_x
and to paste in visual mode without updating the default register:
vnoremap p "_dP