stackoverflow has a few features that help with this; I think the single most useful step you can take is disabling the ability of anonymous users and new accounts to vote. This way, no one can sign up for hundreds of accounts and use their one vote to overpower other users. I'd say requiring a few posts or membership for a certain period of time are both decent options.
Some would say you could allow one vote per IP address to help address this, but I've played plenty of games where malicious users with a nigh-infinite number of proxies defied IP address-based security. It's a deterrent, but a savvy user will get around it easily.
