I\'ve been using WxPython and I\'ve tried Tk, but it seems that, while both are good and I\'ll likely use them for other projects, neither of those appear to be capable of accom
I can't tell you what is best because that is subjective but I can give you another option: PyGTK
PyGTK lets you to easily create programs with a graphical user interface using the Python programming language. The underlying GTK+ library provides all kind of visual elements and utilities for it and, if needed, you can develop full featured applications for the GNOME Desktop.
PyGTK applications are truly multiplatform and they're able to run, unmodified, on Linux, Windows, MacOS X and other platforms.