I may be doing something wrong, but I have been trying to install pyside on Mac 10.12 (Sierra). Here is what I tried (after installing Qt with brew):
I still not have a solution, but I found an alternative.
First of all, I am not an expert (I am super new coding). Based on my own experience below you will find a solution as well.
I need to clarify something first, there are two ways to use this GUI QT - PyQt by Riverbank Computing or(and) PySide, originally developed by Nokia.
I tried many differents ways to install PySide on my MacOS Sierra version10.12.5, but no success, so I ended up finding PyQt, that does the same thing.
Watching this video I installed the PyQT5 in my Mac OS and now it is working. https://www.youtube.com/watch?v=2kHk8ZjxH64
Example of Hello World using PyQT http://pythoncentral.io/intro-to-pysidepyqt-basic-widgets-and-hello-world/
The wiki.qt.io says "PySide has included support for Python 3.2 since version 1.0.8." but it doesn't work for me.
Good lucky.