I may be doing something wrong, but I have been trying to install pyside on Mac 10.12 (Sierra). Here is what I tried (after installing Qt with brew):
You need QT4 to install PySide on 10.11 (not sure about 10.12).
Install QT5 either via Brew or via installer, get cmake via brew and get the latest PySide source (https://pypi.python.org/packages/source/P/PySide/PySide-1.2.4.tar.gz
) Run the following to get Qt4:
brew tap cartr/qt4
brew tap-pin cartr/qt4
brew install qt_4
Once you do so; cd in the source folder and run the following to build:
python setup.py bdist_wheel --ignore-git --qmake=[QMAKE_FROM_QT4_PATH] --cmake=[YOUR_CMAKE_PATH]
cd dist
pip install [YOUR_BUILT_PYSIDE_WHEEL]
Once you do so, you can check that PySide is working correctly, opening a Python console and typing import PySide