When opening e.g. a spreadsheet with pywin32, I found two options to do so:
excel1 = win32com.client.DispatchEx(\'Excel.Application\') wb = excel1.Workbooks.Open
If you're using COM to automate, say, Excel there will come a time when you want .Dispatch to fire up a new instance of the application, not to interfere with the one already running on the desktop.
Use DispatchEx instead of Dispatch