The NuMega True Time profiler lives on in DevPartner Studio by Micro Focus. It provides line and method level detail for .NET apps requiring only PDBs, no source needed (but it helps.) It can discriminate between algorithmically heavy routines versus those with long I/O waits using our proprietary per thread kernel mode timing driver. Version 10.5 ships with new 64-process support on February 4, 2011. Shameless plug: I work on the DevPartner product line. Follow up at http://www.DevPartner.com for news of the 10.5 launch.
Disclaimer: I am the Product Manager for DevPartner at Micro Focus.