Well, you start with cursor on your text, Ctrl+H and type replacement. But surprisingly i was not able to found any shorcut for actual replace or replace a
I have the same issue with Spyder, I don't know why this has not been implemented in the editor.
The work around I currently have for multiple replace is to :
Copy the replacement term to the clipboard
Search(Find/Replace) for the term to replace
Use F3 to select the next term
Use paste Ctrl+V to replace it
Back to step [3] to find the next term
Hope this helps!
EDIT:
According to Spyder dev @carlos below. Since v3.2 This has now been implemented and you may just press and move to the next term.