I am writing a code to take an enormous textfile (several GB) N lines at a time, process that batch, and move onto the next N lines until I have completed the entire file.
islice() can be used to get the next n items of an iterator. Thus, list(islice(f, n)) will return a list of the next n lines of the file f. Using this inside a loop will give you the file in chunks of n lines. At the end of the file, the list might be shorter, and finally the call will return an empty list.
from itertools import islice
with open(...) as f:
while True:
next_n_lines = list(islice(f, n))
if not next_n_lines:
break
# process next_n_lines
An alternative is to use the grouper pattern:
with open(...) as f:
for next_n_lines in izip_longest(*[f] * n):
# process next_n_lines