I am testing WPF DataGrid in hopes of replacing some winforms controls, and so far have been very pleased with the development process. Performance seems to be my biggest concer
A general tip for DataGrid performance issues: I had a problem with the DataGrid in which it took literally seconds to refresh after a window resize, column sort, etc. and locked up the window UI while it was doing so (1000 rows, 5 columns).
It came down to an issue (bug?) with the WPF sizing calculations. I had it in a grid with the RowDefinition Height="Auto" which was causing the rendering system to try and recalculate the size of the DataGrid at runtime by measuring the size of each and every column and row, presumably by filling the whole grid (as I understand it). It is supposed to handle this intelligently somehow but in this case it was not.
A quick check to see if this is a related problem is to set the Height and Width properties of the DataGrid to a fixed size for the duration of the test, and try running again. If your performance is restored, a permanent fix may be among these options: