由于工作环境，我的工作机是在离线环境下的，没法连接外网。但是自己又想学习一下wxpython，只好自己手动离线安装，本来以为很简单的，但是实际上。。。一言难尽。
基本环境：python pip easy_install
直接下载msi数据包安装，如果无法识别安装，那么：
1、确定msi数据包的完整性，包括大小、格式；
python3.X 安装更为简单，直接双击.exe文件安装即可，且都需要选定添加环境变量。
下载地址：https://pypi.org/project/wxPython/4.0.1/#files
选择对应的文件进行安装，我的选择是： wxPython-4.0.1-cp27-cp27m-win_amd64.whl
其中：
cp27 表示 python2.7
win_amd64 表示 windows 64λ
在这之外：win32 表示 32λ 。
将下载好的wxpython**.whl文件转移到python安装路径下的Scripts目录下，我的是：C:\Python27\Scripts
然后打开cmd或者powershell，切换到该目录下：
PS C:\User\Yanta> cd C:\Python27\Scripts执行命令 pip install wxPython-4.0.1-cp27-cp27m-win_amd64.whl ，此时会报错：wxPython-4.0.1-cp27-cp27m-win_amd64.whl is not a supported wheel on this platform. 。
PS C:\Python27\Scripts> pip install .\wxPython-4.0.1-cp27-cp27m-win_amd64.whl wxPython-4.0.1-cp27-cp27m-win_amd64.whl is not a supported wheel on this platform.此时可以尝试使用easy_install安装，结果提示缺少 six 包。
PS C:\Python27\Scripts> .\easy_install-2.7.exe .\wxPython-4.0.1-cp27-cp27m-win_amd64.whl Processing wxPython-4.0.1-cp27-cp27m-win_amd64.whl c:\python27\lib\site-packages\setuptools\pep425tags.py:89: RuntimeWarning: Config variable 'Py_DEBUG' is unset, Python ABI tag may be incorrect warn=(impl == 'cp')): c:\python27\lib\site-packages\setuptools\pep425tags.py:93: RuntimeWarning: Config variable 'WITH_PYMALLOC' is unset, Python ABI tag may be incorrect warn=(impl == 'cp')): c:\python27\lib\site-packages\setuptools\pep425tags.py:99: RuntimeWarning: Config variable 'Py_UNICODE_SIZE' is unset, Python ABI tag may be incorrect sys.version_info < (3, 3))) \ Installing wxPython-4.0.1-cp27-cp27m-win_amd64.whl to c:\python27\lib\site-packages writing requirements to c:\python27\lib\site-packages\wxPython-4.0.1-py2.7-win-amd64.egg\EGG-INFO\requires.txt Adding wxPython 4.0.1 to easy-install.pth file Installing wxdemo-script.py script to c:\python27\Scripts Installing wxdemo.exe script to c:\python27\Scripts Installing img2png-script.py script to c:\python27\Scripts Installing img2png.exe script to c:\python27\Scripts Installing pyslices-script.py script to c:\python27\Scripts Installing pyslices.exe script to c:\python27\Scripts Installing img2py-script.py script to c:\python27\Scripts Installing img2py.exe script to c:\python27\Scripts Installing pyslicesshell-script.py script to c:\python27\Scripts Installing pyslicesshell.exe script to c:\python27\Scripts Installing wxget-script.py script to c:\python27\Scripts Installing wxget.exe script to c:\python27\Scripts Installing helpviewer-script.py script to c:\python27\Scripts Installing helpviewer.exe script to c:\python27\Scripts Installing pyshell-script.py script to c:\python27\Scripts Installing pyshell.exe script to c:\python27\Scripts Installing pycrust-script.py script to c:\python27\Scripts Installing pycrust.exe script to c:\python27\Scripts Installing wxdocs-script.py script to c:\python27\Scripts Installing wxdocs.exe script to c:\python27\Scripts Installing pywxrc-script.py script to c:\python27\Scripts Installing pywxrc.exe script to c:\python27\Scripts Installing img2xpm-script.py script to c:\python27\Scripts Installing img2xpm.exe script to c:\python27\Scripts Installed c:\python27\lib\site-packages\wxpython-4.0.1-py2.7-win-amd64.egg Processing dependencies for wxPython==4.0.1 Searching for six Reading https://pypi.python.org/simple/six/ Download error on https://pypi.python.org/simple/six/: [Errno 11004] getaddrinfo failed -- Some packages may not be found! Couldn't find index page for 'six' (maybe misspelled?) Scanning index of all packages (this may take a while) Reading https://pypi.python.org/simple/ Download error on https://pypi.python.org/simple/: [Errno 11004] getaddrinfo failed -- Some packages may not be found! No local packages or working download links found for six error: Could not find suitable distribution for Requirement.parse('six')然后安装 six ，下载地址：https://pypi.org/project/six/#files
选择 six-1.11.0-py2.py3-none-any.whl ，一样拷贝到C:\Python27\Scripts下，使用pip安装：
PS C:\Python27\Scripts> .\easy_install-2.7.exe .\six-1.11.0-py2.py3-none-any.whl Processing six-1.11.0-py2.py3-none-any.whl c:\python27\lib\site-packages\setuptools\pep425tags.py:89: RuntimeWarning: Config variable 'Py_DEBUG' is unset, Python ABI tag may be incorrect warn=(impl == 'cp')): c:\python27\lib\site-packages\setuptools\pep425tags.py:93: RuntimeWarning: Config variable 'WITH_PYMALLOC' is unset, Python ABI tag may be incorrect warn=(impl == 'cp')): c:\python27\lib\site-packages\setuptools\pep425tags.py:99: RuntimeWarning: Config variable 'Py_UNICODE_SIZE' is unset, Python ABI tag may be incorrect sys.version_info < (3, 3))) \ Installing six-1.11.0-py2.py3-none-any.whl to c:\python27\lib\site-packages Adding six 1.11.0 to easy-install.pth file Installed c:\python27\lib\site-packages\six-1.11.0-py2.7.egg Processing dependencies for six==1.11.0 Finished processing dependencies for six==1.11.0此时再次使用easy_install安装wxpython即可：
PS C:\Python27\Scripts> .\easy_install-2.7.exe .\wxPython-4.0.1-cp27-cp27m-win_amd64.whl Processing wxPython-4.0.1-cp27-cp27m-win_amd64.whl c:\python27\lib\site-packages\setuptools\pep425tags.py:89: RuntimeWarning: Config variable 'Py_DEBUG' is unset, Python ABI tag may be incorrect warn=(impl == 'cp')): c:\python27\lib\site-packages\setuptools\pep425tags.py:93: RuntimeWarning: Config variable 'WITH_PYMALLOC' is unset, Python ABI tag may be incorrect warn=(impl == 'cp')): c:\python27\lib\site-packages\setuptools\pep425tags.py:99: RuntimeWarning: Config variable 'Py_UNICODE_SIZE' is unset, Python ABI tag may be incorrect sys.version_info < (3, 3))) \ removing 'c:\python27\lib\site-packages\wxPython-4.0.1-py2.7-win-amd64.egg' (and everything under it) Installing wxPython-4.0.1-cp27-cp27m-win_amd64.whl to c:\python27\lib\site-packages writing requirements to c:\python27\lib\site-packages\wxPython-4.0.1-py2.7-win-amd64.egg\EGG-INFO\requires.txt wxPython 4.0.1 is already the active version in easy-install.pth Installing wxdemo-script.py script to c:\python27\Scripts Installing wxdemo.exe script to c:\python27\Scripts Installing img2png-script.py script to c:\python27\Scripts Installing img2png.exe script to c:\python27\Scripts Installing pyslices-script.py script to c:\python27\Scripts Installing pyslices.exe script to c:\python27\Scripts Installing img2py-script.py script to c:\python27\Scripts Installing img2py.exe script to c:\python27\Scripts Installing pyslicesshell-script.py script to c:\python27\Scripts Installing pyslicesshell.exe script to c:\python27\Scripts Installing wxget-script.py script to c:\python27\Scripts Installing wxget.exe script to c:\python27\Scripts Installing helpviewer-script.py script to c:\python27\Scripts Installing helpviewer.exe script to c:\python27\Scripts Installing pyshell-script.py script to c:\python27\Scripts Installing pyshell.exe script to c:\python27\Scripts Installing pycrust-script.py script to c:\python27\Scripts Installing pycrust.exe script to c:\python27\Scripts Installing wxdocs-script.py script to c:\python27\Scripts Installing wxdocs.exe script to c:\python27\Scripts Installing pywxrc-script.py script to c:\python27\Scripts Installing pywxrc.exe script to c:\python27\Scripts Installing img2xpm-script.py script to c:\python27\Scripts Installing img2xpm.exe script to c:\python27\Scripts Installed c:\python27\lib\site-packages\wxpython-4.0.1-py2.7-win-amd64.egg Processing dependencies for wxPython==4.0.1 Finished processing dependencies for wxPython==4.0.1安装过后测试一下，是否可以导入wx包：
PS C:\Python27\Scripts> py -2 Python 2.7.15 (v2.7.15:ca079a3ea3, Apr 30 2018, 16:30:26) [MSC v.1500 64 bit (AMD64)] on win32 Type "help", "copyright", "credits" or "license" for more information. >>> import wx4、NOTE
本机安装有python2.7和3.6两个版本，使用py -2 和py -3分别指向2.7和3.6，在python脚本中使用：
#!/user/bin/env python2 #!/user/bin/env python3分别指定即可。
文章来源: 离线安装wxpython