I'm trying to use Fontcustom to create an icon font using svg files and fontforge. I'm on OSX.7. However, whenever I run the program I get the error
Could not find platform independent libraries <prefix>
Could not find platform dependent libraries <exec_prefix>
Consider setting $PYTHONHOME to <prefix>[:<exec_prefix>]
ImportError: No module named site`
As a Python/Unix newbie I don't even know where to start trying to solve this. Can anyone offer any advice? What are <prefix> and <exec_prefix> referring to?
When I type python --version I get Python 2.7.1. And in the directory /System/Library/Frameworks/Python.framework/Versions/2.7/lib/python2.7, there is a big list of modules, and site.py is definitely in that folder. How can I get my computer to find the modules?
If you made a virtual env, then deleted that python installation, you'll get the same error. Just rm -r your venv folder, then recreate it with a valid python location and do pip install -r requirements.txt and you'll be all set (assuming you got your requirements.txt right).
Try export PYTHONHOME=/usr/local. Python should be installed in /usr/local on OS X.
This answer has received a little more attention than I anticipated, I'll add a little bit more context.
Normally, Python looks for its libraries in the paths prefix/lib and exec_prefix/lib, where prefix and exec_prefix are configuration options. If the PYTHONHOME environment variable is set, then the value of prefix and exec_prefix are inherited from it. If the PYTHONHOME environment variable is not set, then prefix and exec_prefix default to /usr/local (and I believe there are other ways to set prefix/exec_prefix as well, but I'm not totally familiar with them).
Normally, when you receive the error message Could not find platform independent libraries <prefix>, the string <prefix> would be replaced with the actual value of prefix. However, if prefix has an empty value, then you get the rather cryptic messages posted in the question. One way to get an empty prefix would be to set PYTHONHOME to an empty string. More info about PYTHONHOME, prefix, and exec_prefix is available in the official docs.
change PYTHONHOME to the parent folder of the bin file of python, like /usr，which is the parent folder of /usr/bin.
I had this problem and spent a few hours trying to fix it. I fixed the prefix error by changing the path but I still had an encoding import error. This was fixed by restarting my computer.
(I wrote this so that the next person to have this issue does not have to spend a few hours on it like I did.)
My pycharm ce had the same error, was easy to fix it, if someone has that error, just uninstall and delete the folder, use ctrl+h if you can't find the folder in your documents, install the software again and should work again.
Remember to save the scratches folder before erasing the pycharm folder.
When the first lion of python script is #!/usr/bin/env python，maybe it's /usr/bin/env issue. You can run /usr/bin/env to see if error ,if it runs with error,you can update /usr/bin/env with yum(and so on) install coreutils.
来源：https://stackoverflow.com/questions/19292957/how-can-i-troubleshoot-python-could-not-find-platform-independent-libraries-pr