I had some test sites setup on a server that had one IP and utilized different ports for the site like this.
www.acme.com:5000 www.acme.com:6000
This worked great until a SSL certificate was installed on the server. Now the sites above are not coming up.
How do I configure them so that they come up again?
SSL can only segmented by IP and Port. You can however can run SSL over a different port than 443 by simply adding a binding for https and a different port.
In IIS 7.x, in the Bindings for the site, you would add one for SSL and change the port:
What would also need to happen, which isn't shown in this image is the selection of the appropriate SSL certificate which would need to be configured on the server. With that set, you would then access the site by going to:
https://mysite:1234/...
来源：https://stackoverflow.com/questions/5734150/multiple-websites-on-same-ip-with-different-ports-withiis