I've tried install Apache, PHP, MySQL, and PHPMyAdmin manually and got the error. Then tried XAMPP and still got the error this error with PHPMyAdmin:
The mysql extension is missing. Please check your PHP configuration. <a href="Documentation.html#faqmysql" target="documentation"><img class="icon" src="./themes/pmahomme/img/b_help.png" width="11" height="11" alt="Documentation" title="Documentation" /></a>
I'm clueless of what the issue is. I've tried solutions on the web and none worked so far. This is a new Windows installation and I installed XAMPP on C:.
Fairly simple fix. Find your PHP.ini file, and in it there will be a list of extensions. Look for the one that says mysql and take the ; off the front of the line.
;extension=php_mysql.dll
;extension=php_mysqli.dll
;extension=php_pdo_mysql.dll
If you don't know where your PHP.ini file resides, you can put this code in a script to find out:
phpinfo()
If after you've removed the semi-colons you STILL get this error. Your extension_dir value in php.ini may be the problem simply point the value to extension_dir = "C:\php\ext" (or wherever you store your php modules), restart your server and you should be fine.
Just add this to your php.ini
extension= php_mysqli.dll
and stop and start apache and MySQL it will work.
来源：https://stackoverflow.com/questions/6617288/phpmyadmin-windows-xampp-missing-mysql-extension-issue