pyodbc is a very nice thing, but the Windows installers only work with their very specific python version. With the release of Python 3.4, the only available installers just stop once they don't see 3.3 in the registry (though 3.4 is certainly there).
Copying the .pyd and .egg-info files from a 3.3 installation into the 3.4 site-packages directory doesn't seem to do the trick. When importing pyodbc, an ImportError is thrown: ImportError: DLL load failed: %1 is not a valid Win32 application.
Is there a secret sauce that can be added to make the 3.3 file work correctly? Or do we just need to wait for a 3.4 installer version?
The different versions of Python are (for the most part) not binary-compatible, and thus any compiled extensions (such as pyodbc) will only work for a specific version.
Note that pure-Python packages (the ones that are completely written in Python, and have no non-Python dependencies) do not need to be compiled, and thus can be written to support multiple Python versions.
Also note that it is technically possible for a compiled extension to be written such that it works for Python 3.2 as well as 3.3, 3.4, and the future 3.x's to come, but they have to limit themselves to the "stable ABI" as specified by PEP 384, and most extensions do not do this. As far as I know, pyodbc is not limited to the stable ABI and must be compiled separately for each Python version.
That said, it is also possible to compile your own version of pyodbc from source, as long as you have the required tools and expertise. (But I'm guessing if you're asking this question, you don't. I don't either, otherwise I'd include some tips in this answer.)
As you have already commented, pypyodbc may be your best bet, as it is a pure-Python package.
Installing pypyodbc can be done via the commandline:
C:\Python34\Scripts>pip install pypyodbc
Using it as drop-in replacement of pyodbc can be done using:
import pypyodbc as pyodbc
[The current version of pyodbc at the time of this edit is 3.0.10, and it does support Python 3.4. Of course, it's still useful to be aware of pypyodbc in case pyodbc falls behind again when future versions of Python are released.]
Did you try to download from here? It has an unofficial build for 3.4. I did a quick test myself, looks like it's working fine for me.
I fixed this by installing pyodbc 3.0.10. The latest version of pyodbc didn't work on Windows with Python 3.4
However pyodbc 3.0.10 did work for me
Install command on command prompt : pip install pyodbc 3.0.10
来源：https://stackoverflow.com/questions/23299034/pyodbc-and-python-3-4-on-windows